2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-α-D-arabinofuranosyl)-5-methyl- - Names and Identifiers
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-α-D-arabinofuranosyl)-5-methyl- - Physico-chemical Properties
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-α-D-arabinofuranosyl)-5-methyl- - Upstream Downstream Industry
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-α-D-arabinofuranosyl)-5-methyl- - Introduction
2,4(1H,3H)-Pyrimidinedione, 1-(1H)-5-methyl-(or FdUMP for short) is an organic compound, it is a chemical analog to replace thymine.
Properties of the compound:
-Appearance: Colorless solid
-Molecular formula: C10H12N2O6F
-Molecular weight: 282.21g/mol
-Melting point: About 176-179 degrees Celsius
The main use of FdUMP is as an anti-cancer drug, the most common application of which is the treatment of colorectal cancer. The compound inhibits the production of thymine by inhibiting pyrimidine synthase, thereby interfering with the DNA synthesis and proliferation of cancer cells.
The method of preparing FdUMP mainly includes two steps. First, 1-(2-deoxy-2-fluoro-α-d-arabinofuranosyl)-5-methylpurine (precursor of FdUMP) was prepared by chemical synthesis. A chemical reaction is then used to convert the precursor of FdUMP into FdUMP.
Regarding safety information, FdUMP is a strongly cytotoxic compound that may cause harm to human systems and the environment. Strict operation and protective measures are required to ensure safety. Prior to any use or handling of this compound, relevant safety guidelines and laboratory procedures should be understood and followed in detail.
Last Update:2024-04-09 21:01:54